In general, steroid injections are given with a local anesthetic, usually Lidocaine, to help control inflammatory reaction in bursae, around tendons, ligaments, and in joints. The local anesthetic will usually numb the area for several hours. If a long-acting anesthetic, such as Marcaine, is used, it may remain numb up to 6-8 hours. The steroid in the injection will become effective in 2-3 days and may last for several weeks to months or may resolve the problem completely. The effectiveness for relief of pain and inflammation in steroid injections is not always predictable.